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        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
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      <link:roleType id="StockBasedCompensationStockOptionActivityDetails" roleURI="http://www.globusmedical.com/role/StockBasedCompensationStockOptionActivityDetails">
        <link:definition>2434404 - Disclosure - STOCK-BASED COMPENSATION (Stock Option Activity) (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
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      <link:roleType id="StockBasedCompensationTables" roleURI="http://www.globusmedical.com/role/StockBasedCompensationTables">
        <link:definition>2334301 - Disclosure - STOCK-BASED COMPENSATION (Tables)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockBasedCompensationTextualsDetails" roleURI="http://www.globusmedical.com/role/StockBasedCompensationTextualsDetails">
        <link:definition>2434402 - Disclosure - STOCK-BASED COMPENSATION (Textuals) (Details)</link:definition>
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        <link:usedOn>link:calculationLink</link:usedOn>
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  <xsd:element abstract="true" id="gmed_A2003and2008StockPlansMember" name="A2003and2008StockPlansMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
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  <xsd:element id="gmed_AccruedLiabilitiesLegalAndOtherSettlementsAndExpenses" name="AccruedLiabilitiesLegalAndOtherSettlementsAndExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="gmed_AccumulatedOtherComprehenseiveIncomeAbstract" name="AccumulatedOtherComprehenseiveIncomeAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_AccumulatedOtherComprehensiveIncomeAbstract" name="AccumulatedOtherComprehensiveIncomeAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_AcquiredIntangibleAssetsLineItems" name="AcquiredIntangibleAssetsLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_Acquisitions2012Member" name="Acquisitions2012Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_AltusPartnersLlcMember" name="AltusPartnersLlcMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_AvailableForSaleSecuritiesContractualMaturity" name="AvailableForSaleSecuritiesContractualMaturity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="gmed_BackgroundAndSummaryOfSignificantAccountingPoliciesAbstract" name="BackgroundAndSummaryOfSignificantAccountingPoliciesAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
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  <xsd:element id="gmed_BusinessAcquisitionLiabilitiesNoncurrent" name="BusinessAcquisitionLiabilitiesNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element id="gmed_CashEquivalentsFairValueDisclosure" name="CashEquivalentsFairValueDisclosure" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element id="gmed_Combinedlitigationloss" name="Combinedlitigationloss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_CommitmentsAndContingenciesLineItems" name="CommitmentsAndContingenciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_CommitmentsAndContingenciesTable" name="CommitmentsAndContingenciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_CommonStockNumberOfVotesPerShare" name="CommonStockNumberOfVotesPerShare" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ConversionOfClassBCommonStockToClassCommonStockMember" name="ConversionOfClassBCommonStockToClassCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ConversionOfClassBCommonStockToClassCommonStockSellingStockholdersMember" name="ConversionOfClassBCommonStockToClassCommonStockSellingStockholdersMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ConversionOfClassCCommonStockToClassCommonStockMember" name="ConversionOfClassCCommonStockToClassCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ConversionOfSeriesEPreferredStockToClassBCommonStockMember" name="ConversionOfSeriesEPreferredStockToClassBCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_ConversionOfStockRequirementsMaximumOwnershipPercentage" name="ConversionOfStockRequirementsMaximumOwnershipPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_DeiAbstract" name="DeiAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_DisruptiveTechnologyMember" name="DisruptiveTechnologyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_EquityOwnershipAmountDomain" name="EquityOwnershipAmountDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_EquityOwnershipByAmountAxis" name="EquityOwnershipByAmountAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_EquityOwnershipOfLessThanTenPercentMember" name="EquityOwnershipOfLessThanTenPercentMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_InnovativeFusionMember" name="InnovativeFusionMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
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  <xsd:element id="gmed_IntangibleAssetsAcquiredAsPartOfBusinessCombinationTableTextBlock" name="IntangibleAssetsAcquiredAsPartOfBusinessCombinationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_IntangibleAssetsDisclosureAbstract" name="IntangibleAssetsDisclosureAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_IntangibleAssetsGross" name="IntangibleAssetsGross" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="gmed_InternationalMember" name="InternationalMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
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  <xsd:element id="gmed_LineOfCreditTerminationPeriodWithoutPenalty" name="LineOfCreditTerminationPeriodWithoutPenalty" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_LineOfCreditVariableRatePerAnnumMember" name="LineOfCreditVariableRatePerAnnumMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_MedicalDeviceExciseTax" name="MedicalDeviceExciseTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="gmed_MedicalDeviceExciseTaxPercentage" name="MedicalDeviceExciseTaxPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_MedicalDeviceExciseTaxPolicyTextBlock" name="MedicalDeviceExciseTaxPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_NSpineAndSynthesLitigationMember" name="NSpineAndSynthesLitigationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_NewSharesIssuedByCompanyMember" name="NewSharesIssuedByCompanyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_NumberOfProductCategories" name="NumberOfProductCategories" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_NumberOfProductsLaunchedSinceInception" name="NumberOfProductsLaunchedSinceInception" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="gmed_NuvasiveIncMember" name="NuvasiveIncMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_OperatingCostsDomain" name="OperatingCostsDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_PaymentOfBusinessAcquisitionLiabilities" name="PaymentOfBusinessAcquisitionLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element id="gmed_ProceedsFromIssuanceInitialPublicOfferingNetOfUnderwritingFeesAndOfferingExpenses" name="ProceedsFromIssuanceInitialPublicOfferingNetOfUnderwritingFeesAndOfferingExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
  <xsd:element id="gmed_ProceedsFromIssuanceOfCommonAndPreferredStock" name="ProceedsFromIssuanceOfCommonAndPreferredStock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration" />
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  <xsd:element id="gmed_ReverseStockSplitConversionRatio" name="ReverseStockSplitConversionRatio" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant" />
  <xsd:element id="gmed_ReverseStockSplitProposedConversionRatio" name="ReverseStockSplitProposedConversionRatio" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
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  <xsd:element id="gmed_ScheduleOfRevenueFromExternalCustomersByGeographicalAreaInternationalAndDomesticTableTextBlock" name="ScheduleOfRevenueFromExternalCustomersByGeographicalAreaInternationalAndDomesticTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ScheduleOfSalesByGeographicAreaLineItems" name="ScheduleOfSalesByGeographicAreaLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_ScheduleOfSalesByGeographicAreaTable" name="ScheduleOfSalesByGeographicAreaTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualPercentageIncreaseInSharesAvailableForIssuance" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAnnualPercentageIncreaseInSharesAvailableForIssuance" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant" />
  <xsd:element id="gmed_ShareBasedCompensationArrangementByShareBasedPaymentAwardBaseNumberOfSharesIssuable" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardBaseNumberOfSharesIssuable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="instant" />
  <xsd:element id="gmed_ShareBasedCompensationByShareBasedPaymentMaximumContractualTerm" name="ShareBasedCompensationByShareBasedPaymentMaximumContractualTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_ShareBasedCompensationNumberOfStockPlans" name="ShareBasedCompensationNumberOfStockPlans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant" />
  <xsd:element abstract="true" id="gmed_StockOfferingInitialPublicOfferingTransactionAxis" name="StockOfferingInitialPublicOfferingTransactionAxis" nillable="true" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_StockOfferingInitialPublicOfferingTransactionDomain" name="StockOfferingInitialPublicOfferingTransactionDomain" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element id="gmed_StockOptionCompensationExpenseAndIntrinsicValueScheduleTableTextBlock" name="StockOptionCompensationExpenseAndIntrinsicValueScheduleTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" nillable="true" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_SynthesUsaLlcSynthesUsaProductsLlcAndSynthesUsaSalesLlcLitigationMember" name="SynthesUsaLlcSynthesUsaProductsLlcAndSynthesUsaSalesLlcLitigationMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration" />
  <xsd:element abstract="true" id="gmed_TextualsAbstract" name="TextualsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration" />
</xsd:schema>